Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Role of angiopoietin-2 in vascular physiology and pathophysiology
Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …
Mechanisms of dysfunction in the aging vasculature and role in age-related disease
AJ Donato, DR Machin, LA Lesniewski - Circulation research, 2018 - Am Heart Assoc
Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …
United States and many developed nations. Two major age-related arterial phenotypes …
[HTML][HTML] The role of estrogen in insulin resistance: a review of clinical and preclinical data
M De Paoli, A Zakharia, GH Werstuck - The American journal of pathology, 2021 - Elsevier
Insulin resistance results when peripheral tissues, including adipose, skeletal muscle, and
liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This …
liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This …
Hypertension, diabetes, atherosclerosis and NASH: cause or consequence?
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of
chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD …
chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD …
Endothelial function in cardiovascular medicine: a consensus paper of the European society of cardiology working groups on atherosclerosis and vascular biology …
Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …
70-year legacy of the Framingham Heart Study
Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
Targeting vascular (endothelial) dysfunction
A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
M Mirabelli, E Chiefari, B Arcidiacono, DM Corigliano… - Nutrients, 2020 - mdpi.com
Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is
a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide …
a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide …
Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology
CW Tsao, RS Vasan - International journal of epidemiology, 2015 - academic.oup.com
Abstract The Framingham Heart Study (FHS) has conducted seminal research defining
cardiovascular disease (CVD) risk factors and fundamentally shaping public health …
cardiovascular disease (CVD) risk factors and fundamentally shaping public health …