The landscape of isoform switches in human cancers
K Vitting-Seerup, A Sandelin - Molecular Cancer Research, 2017 - AACR
Alternative usage of transcript isoforms from the same gene has been hypothesized as an
important feature in cancers. However, differential usage of gene transcripts between …
important feature in cancers. However, differential usage of gene transcripts between …
Statistical characterization and classification of colon microarray gene expression data using multiple machine learning paradigms
Objective A colon microarray data is a repository of thousands of gene expressions with
different strengths for each cancer cell. It is necessary to detect which genes are responsible …
different strengths for each cancer cell. It is necessary to detect which genes are responsible …
Comparison of alternative splicing junction detection tools using RNASeq data
Background: Alternative splicing (AS) is a posttranscriptional process that produces different
transcripts from the same gene and is important to produce diverse protein products in …
transcripts from the same gene and is important to produce diverse protein products in …
[HTML][HTML] Robustness of differential gene expression analysis of RNA-seq
A Stupnikov, CE McInerney, KI Savage… - Computational and …, 2021 - Elsevier
Abstract RNA-sequencing (RNA-seq) is a relatively new technology that lacks
standardisation. RNA-seq can be used for Differential Gene Expression (DGE) analysis …
standardisation. RNA-seq can be used for Differential Gene Expression (DGE) analysis …
[HTML][HTML] Alternative RNA splicing in stem cells and cancer stem cells: importance of transcript-based expression analysis
Alternative ribonucleic acid (RNA) splicing can lead to the assembly of different protein
isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a …
isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a …
[PDF][PDF] FOXA1 regulates alternative splicing in prostate cancer
Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …
CASH: a constructing comprehensive splice site method for detecting alternative splicing events
W Wu, J Zong, N Wei, J Cheng, X Zhou… - Briefings in …, 2018 - academic.oup.com
Abstract RNA-sequencing (RNA-seq) can generate millions of reads to provide clues for
analyzing novel or abnormal alternative splicing (AS) events in cells. However, current …
analyzing novel or abnormal alternative splicing (AS) events in cells. However, current …
SUVA: splicing site usage variation analysis from RNA-seq data reveals highly conserved complex splicing biomarkers in liver cancer
Most of the current alternative splicing (AS) analysis tools are powerless to analyse complex
splicing. To address this, we developed SUVA (Splice sites Usage Variation Analysis) that …
splicing. To address this, we developed SUVA (Splice sites Usage Variation Analysis) that …
Trends and application of data science in bioinformatics
Advancement of sequencing technologies, rapid advances in omics generated an extensive
volume of biological data in recent years. It requires sophisticated analytical tools to analyze …
volume of biological data in recent years. It requires sophisticated analytical tools to analyze …
[HTML][HTML] A method based on differential entropy-like function for detecting differentially expressed genes across multiple conditions in RNA-Seq studies
The advancement of high-throughput RNA sequencing has uncovered the profound truth in
biology, ranging from the study of differential expressed genes to the identification of …
biology, ranging from the study of differential expressed genes to the identification of …