Since the 1970s, the proportion of overweight and obese people in the U nited S tates has
grown at an alarming rate. An awareness of the consequences of obesity on the health and …

In numerous epidemiologic, clinical, and experimental studies, dietary sodium intake has
been linked to blood pressure, and a reduction in dietary salt intake has been documented …

A 57-year-old woman is seen in an outpatient clinic, where her blood pressure reading is
155/95 mm Hg. Dietary therapy is recommended. Dietary changes that have been shown to …

Mutations increasing WNK1 kinase expression in humans cause the
pseudohypoaldosteronism type II hypertension syndrome. This condition is treated …

A 67-year-old woman is referred by her primary care physician for treatment of osteoporosis
and progressive bone loss. Oral bisphosphonate therapy is recommended …

It has recently been shown that the WNK [with-no-K (Lys)] kinases (WNK1, WNK2, WNK3
and WNK4) have vital roles in the control of salt homeostasis and blood pressure. This …

Nutrition science is a highly fractionated, contentious field with rapidly changing viewpoints
on both minor and major issues impacting on public health. With an evolutionary perspective …

Ion cotransporters, such as the Na+/Cl− cotransporter (NCC), control renal salt re-absorption
and are regulated by the WNK-signalling pathway, which is over-stimulated in patients …

Background Several healthful dietary patterns appear to be effective at lowering blood
pressure and preventing hypertension. However, the relationship between dietary patterns …

Hypertension is the single most important and modifiable risk factor for cardiovascular
morbidity and mortality worldwide. Non pharmacologic interventions, in particular dietary …