Highlights•Th17 cells and cytokines are associated with the more severe phenotypes of
asthma.•IL-17A and IL-17F are associated with increased neutrophils in the airway.•IL-17A …

Introduction: Asthma is a respiratory disorder typically characterized by T-helper type 2 (Th2)
inflammation that is mediated by cytokines, including IL-4, IL-5, and IL-13 …

Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

Sex hormones regulate many autoimmune and inflammatory diseases, including asthma. As
adults, asthma prevalence is 2-fold greater in women compared to men. The number of …

Dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent seronegative
inflammatory arthritis and psoriasis that form part of the spondyloarthropathy spectrum. We …

Th17 cells are generally considered to be positive regulators of immune responses because
they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22. Cytokine …

The most recent Guidelines for the Diagnosis and Management of Asthma from the National
Asthma Education and Prevention Program define the disease as follows:“Asthma is a …

As adults, women are twice as likely as men to have asthma; however, the mechanisms
explaining this sexual dimorphism remain unclear. Increased type 2 cytokines and/or IL-17A …

Increasing evidence indicated that excess salt consumption can impose risks on human
health and a reduction in daily salt intake from the current average of approximately 12 g/d …

The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …