Airborne particulate matter (PM) has become a serious health issue causing pulmonary
diseases such as asthma. Due to the side effects and non-specificity of conventional drugs …

Severe asthma develops as a result of heightened, persistent symptoms that generally
coincide with pronounced neutrophilic airway inflammation. In individuals with severe …

Background: Interleukin-17 (IL-17) and Rho-kinase (ROCK) play an important role in
regulating the expression of inflammatory mediators, immune cell recruitment, hyper …

Type 2 cytokine-driven immune responses are important against parasite infections but also
underlie the development of inflammatory allergic diseases. Type 2 CD4+ T (Th2) cells have …

Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants
annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play …

Th17 cell responses orchestrate immunity against extracellular pathogens but also underlie
autoimmune disease pathogenesis. In this study, we uncovered a distinct and critical role for …

Non-communicable, chronic respiratory diseases (CRDs) affect millions of individuals
worldwide. The course of these CRDs (asthma, chronic obstructive pulmonary disease, and …

Killer cell Ig–like receptors (KIRs) on NK cells have been linked to a wide spectrum of health
conditions such as chronic infections, autoimmune diseases, pregnancy complications …

Calprotectin is a heterodimer of the proteins S100A8 and S100A9, and it is an abundant
innate immune protein associated with inflammation. In humans, calprotectin transcription …

Background Interleukin-17, the major proinflammatory cytokine secreted by Th17 cells,
makes essential contribution to pathogenesis of severe asthma, while the detailed …