Abstract IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an
influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in …

Cystic fibrosis (CF) is characterized by an excessive neutrophilic inflammatory response
within the airway as a result of defective cystic fibrosis transmembrane receptor (CFTR) …

Corticosteroid insensitivity in asthma limits the ability to effectively manage severe asthma,
which is characterized by persistent airway inflammation, airway hyperresponsiveness …

T helper 17 (Th17) cells protect against fungal and bacterial infections and are implicated in
autoimmunity. Several long intergenic noncoding RNAs (lincRNA) are induced during Th17 …

Background Immunotherapy for food allergies involves progressive increased exposures to
food that result in desensitization to food allergens in some subjects but not tolerance to the …

BACKGROUND: Interleukin (IL) 17A, a key cytokine of TH17 cells, is a well-known
proinflammatory cytokine. Despite the important role of TH17 cells in acute airway …

African Americans have higher rates of asthma prevalence, morbidity, and mortality in
comparison with other racial groups. We sought to characterize endotypes of childhood …

Background Viral infections are the most frequent cause of asthma exacerbations and are
linked to increased airway reactivity (AR) and inflammation. Mice infected with respiratory …

Mucosal tolerance is induced early in life and is an important mechanism of protection from
diseases, such as asthma. Respiratory syncytial virus (RSV) is a main cause of bronchiolitis …

Background Nonsteroidal anti-inflammatory drugs–exacerbated respiratory disease (N-
ERD) is currently classified as a type-2 (T2) immune-mediated disease characterized by …