Drug discovery and development is a high-risk enterprise that requires significant
investments in capital, time and scientific expertise. The studies of xenobiotic metabolism …

Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

The purpose of the article is to offer an overview of the latest release of the VEGA suite of
programs. This software has been constantly developed and freely released during the last …

Exposure to arsenic-contaminated drinking water is a major threat to human health. Millions
of people across the world are exposed to arsenic-contaminated drinking water with …

As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in
living systems need to be better understood. Our goal was to evaluate the developmental …

Amplex Red is a fluorescent probe that is widely used to detect hydrogen peroxide (H 2 O 2)
in a reaction where it is oxidised to resorufin by horseradish peroxidase (HRP) as a catalyst …

Low drug productivity has been a significant problem of the pharmaceutical industry for
several decades even though numerous novel technologies were introduced during this …

Lupin foods provide useful health benefits. Since tryptic and peptic peptides from lupin
protein modulate cholesterol metabolism in HepG2 cells and increase LDL-uptake, this work …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

Activation of the pregnane X receptor (PXR) and subsequently its target genes, including
those encoding drug transporters and metabolizing enzymes, while playing substantial roles …