Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Meninges that surround the CNS consist of an outer fibrous sheet of dura mater
(pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the …

Progenitor heterogeneity and identities underlying tumor initiation and relapse in
medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we …

Most human cancers develop from stem and progenitor cell populations through the
sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells …

Medulloblastoma, a common pediatric malignant central nervous system tumour, represent
a small proportion of brain tumours in adults. Previously it has been shown that in adults …

Background Recurrent pediatric medulloblastoma and ependymoma have a grim prognosis.
We report a first-in-human, phase I study of intraventricular infusions of ex vivo expanded …

Medulloblastoma is a malignant tumor of the cerebellum and the most frequent malignant
brain tumor in children. The standard of care consists of maximal resection surgery, followed …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …

Introduction Medulloblastoma (MB) is a heterogeneous tumor of the cerebellum that is
divided into four main subgroups with distinct molecular and clinical features. Sonic …

Pineoblastomas (PBs) are rare, aggressive pediatric brain tumors of the pineal gland with
modest overall survival despite intensive therapy. We sought to define the clinical and …