[HTML][HTML] Challenges in developing Geroscience trials
Y Rolland, F Sierra, L Ferrucci, N Barzilai… - Nature …, 2023 - nature.com
Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …
[HTML][HTML] Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
[HTML][HTML] Aging Process and Related Diseases
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …
physiological function and an increased risk of age-related diseases. While aging is a …
[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: a review
D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …
[HTML][HTML] Revisiting the neuroinflammation hypothesis in Alzheimer's disease: A focus on the druggability of current targets
M Wong-Guerra, C Calfio, RB Maccioni… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common form of neurodegenerative disease and
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …
disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia …
aaUrgent Needs of Caregiving in Ageing Populations with Alzheimer's Disease and Other Chronic Conditions: Support Our Loved Ones
The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …
unknown. Several hypotheses attempt to describe the normal ageing process, including …
[HTML][HTML] Targeting NLRP3-mediated neuroinflammation in Alzheimer's disease treatment
J Barczuk, N Siwecka, W Lusa… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in the general population
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …
Focus on senescence: Clinical significance and practical applications
V Boccardi, ME Orr, MC Polidori… - Journal of Internal …, 2024 - Wiley Online Library
The older population is increasing worldwide, and life expectancy is continuously rising,
predominantly thanks to medical and technological progress. Healthspan refers to the …
predominantly thanks to medical and technological progress. Healthspan refers to the …
[HTML][HTML] The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …
changes in both intracellular and extracellular microenvironments that affect the entire body …
[HTML][HTML] Identification and validation of aging-related genes in Alzheimer's disease
Q Zhang, J Li, L Weng - Frontiers in neuroscience, 2022 - frontiersin.org
Aging is recognized as the key risk factor for Alzheimer's disease (AD). This study aimed to
identify and verify potential aging-related genes associated with AD using bioinformatics …
identify and verify potential aging-related genes associated with AD using bioinformatics …