Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Chronic pain during childhood and adolescence can lead to persistent pain problems and
mental health disorders into adulthood. Posttraumatic stress disorders and depressive and …

Pain and depression are frequently co-existent in clinical practice, yet the underlying
mechanisms remain largely to be determined. Microglia activation and subsequent pro …

Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of
patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Tensioning techniqueswere the first neurodynamic techniques used therapeutically in the
management of people with neuropathies. This article aims to provide a balanced evidence …

Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the
pharmacological modulation of neurotransmission from an exclusively neuronal perspective …

Neuropathic pain is a type of pain that persists for a long time and becomes pathological.
Additionally, the anxiodepressive disorders derived from neuropathic pain are difficult to …