Divergence of cis-regulatory elements drives species-specific traits, but how this manifests in
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …

Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

How distal regulatory elements control gene transcription and chromatin topology is not
clearly defined, yet these processes are closely linked in lineage specification during …

Innate immune responses rely on inducible gene expression programmes which, in contrast
to steady-state transcription, are highly dependent on cohesin. Here we address …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Cohesin regulates gene expression through context-specific chromatin folding mechanisms
such as enhancer–promoter looping and topologically associating domain (TAD) formation …

It remains unclear why acute depletion of CTCF and cohesin only marginally affects
expression of most genes despite substantially perturbing 3D genome folding at the level of …

The heart, which is the first organ to develop, is highly dependent on its form to function,.
However, how diverse cardiac cell types spatially coordinate to create the complex …

The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …

The spatial organization of molecules in a cell is essential for their functions. While current
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …