Serrated polyps of the large intestine, including traditional hyperplastic polyps, traditional
serrated adenomas, and more recently described sessile serrated adenomas, have gained …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Colorectal cancer is a heterogeneous disease. There are three main pathways to colorectal
cancer: the chromosomal instability pathway, the CpG island methylator phenotype pathway …

Colorectal cancer (CRC) ranks among the three most common cancers in terms of both
cancer incidence and cancer‐related deaths in most Western countries. Serrated …

BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …

It has been well documented that there are two major pathways in colorectal carcinogenesis.
One is the chromosomal instability pathway (adenoma–carcinoma sequence), which is …

Colorectal cancer is believed to progress through an adenoma–carcinoma sequence.
However, recent evidence increasingly supports the existence of an alternative route for …

Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of
microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas …

Background and aims Patients with hyperplastic polyposis syndrome (HPS) receive
endoscopic surveillance to prevent malignant progression of polyps. However, the optimal …

Human gastric carcinoma shows a higher prevalence of microsatellite instability (MSI) than
does any other type of sporadic human cancer. The reasons for this high frequency of MSI …