Background: Microsatellite instability (MSI) is seen in 10%–15% of sporadic colorectal
cancers mostly in the right colon, but the precursors of cancers with MSI remain unknown …

We compared hyperplastic-like polyps that preceded microsatellite-unstable
adenocarcinomas to incidental hyperplastic polyps to identify distinguishing morphologic …

There is now strong evidence for an alternative pathway of colorectal carcinogenesis
implicating hyperplastic polyps and serrated adenomas. This article briefly reviews the …

Serrated adenoma has been proposed to be a distinct entity among colorectal neoplasms.
Progression to frank carcinoma has been suggested in individual cases, but the prevalence …

Aims: To characterize a series of colorectal polyps, focusing on the clinicopathological
features of serrated adenoma (SA), mixed polyp (MP) and the recently recognized sessile …

Aim: To establish and explain the pattern of molecular signatures across colorectal polyps.
Methods and results: Thirty‐two sessile serrated adenomas (SSA), 10 mixed polyps (MP), 15 …

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer
predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. It is …

This review explores the chief genetic and epigenetic events that promote pathological
progression in colorectal carcinogenesis. This article discusses the molecular and …

Aberrant crypt foci (ACF) are postulated to be the earliest precursor lesion in colorectal
carcinogenesis, and CpG island methylation has been described as an important molecular …

Sessile serrated adenoma (SSA) is the proposed precursor for microsatellite unstable
colorectal carcinomas and some authorities recommend that SSAs should be managed …