Sessile serrated adenomas (SSAs) are associated with colorectal carcinomas (CRCs) that
demonstrate high microsatellite instability (MSI-H). Currently, SSAs are managed clinically in …

Morphological and molecular studies are beginning to distinguish separate evolutionary
pathways for colorectal cancer. The serrated pathway encompassing hyperplastic aberrant …

Serrated adenomas (SA) of the colorectum show features intermediate between hyperplastic
polyps (HP) and adenomas. HP and SA are related lesions and there is now strong …

The serrated polyp pathway is a histopathological sequence that begins in a hyperplastic
polyp, or precursor serrated aberrant crypt focus, and has the potential to end in a colonic …

Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …

Abundant recent data suggest that sessile serrated adenoma/polyp (SSA/P) is an early
precursor lesion in the serrated pathway of carcinogenesis. It is believed that SSA/Ps …

Background & Aims: Patients with hyperplastic polyposis are reported to have multiple
and/or large hyperplastic polyps (HPs) and an increased risk of colorectal cancer, but the …

Serrated colorectal carcinomas (CRCs) are morphologically different from conventional
CRCs and have been proposed to follow a distinct pathway of CRC formation. Despite …

Hyperplastic polyposis is a loosely defined syndrome initially thought not to confer a
clinically important predisposition to colorectal cancer. The aim of the current study was to …

PURPOSE Hyperplastic polyps are usually considered to be an innocent finding with little or
no potential to progress to colorectal cancer. However, recent literature suggests that some …