Serrated adenoma is a recently described entity characterized by having combined
architectural features of hyperplastic polyps and classical adenoma. To understand the role …

Aims: To assess observer agreement in the diagnosis of colorectal serrated polyps, in
particular, serrated adenomas and admixed polyps (ie 'polyps with admixed hyperplastic …

Lynch syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes.
Both microsatellite instability (MSI) testing and immunohistochemical analyses (IHC) of …

Although recognized 25 years ago, the traditional serrated adenoma (TSA) remains an
ongoing source of diagnostic and biologic debate. Recent research has greatly improved …

The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota
and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation …

The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a small
but significant proportion of colorectal cancers. While MSI is identified in most cancers in …

The pathogenesis and risk of malignancy of traditional serrated adenomas (TSAs) are
unclear. In North America, TSAs are relatively uncommon, occur mainly in the left colon, and …

Sessile serrated adenoma (SSA), also referred to as sessile serrated polyp, has been
proposed as a precursor lesion to microsatellite unstable carcinoma. However, the …

Colorectal carcinoma is uncommon in Egypt, but a high proportion of cases occurs before
age 40 years and in the rectum. We compared the molecular pathology of 59 representative …

Abstract Context.—Microsatellite instability (MSI) due to defective mismatch repair (MMR)
genes has been reported in the majority of colorectal tumors from patients with hereditary …