Conclusion. This genetic epidemiological study demonstrated that 26.65% of the prelingual
deafness in Northern Chinese patients can be detected at younger ages by genetic testing …

The past decade has seen extremely rapid progress in the field of hereditary hearing loss.
To date, 80 loci for nonsyndromic hearing loss have been mapped to the human genome …

Purpose: Mutations in the SLC26A4 gene are second only to GJB2 mutations as a currently
identifiable genetic cause of sensorineural hearing loss. In most areas of China, genetic …

Tremendous advances in human genetics have been made in recent years, as the fruits of
the Human Genome Project are facilitating the identification of genes associated with myriad …

Enlargement of the vestibular aqueduct (EVA) is the most common inner ear anomaly
detected in ears of children with sensorineural hearing loss. Pendred syndrome (PS) is an …

Sensorineural hearing defect and goiter are common features of Pendred's syndrome. The
clinical diagnosis of Pendred's syndrome remains difficult because of the lack of sensitivity …

Sulfate transporters in plants and animals are structurally conserved and have an amino-
terminal domain that functions in transport and a carboxyl-terminal region that has been …

Enlargement of the vestibular aqueduct (EVA) is one of the most common inner ear
malformations associated with sensorineural hearing loss in children. The delayed onset …

Mutations in SLC26A4, which encodes pendrin, are responsible for hearing loss with an
enlarged vestibular aqueduct and Pendred syndrome. The most prevalent mutation in East …