Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

The multifactorial nature of some diseases, particularly neurodegenerative diseases such as
Alzheimer's disease, frequently requires the use of several drugs. These drug cocktails are …

In this study, we investigated the conjugation of theophylline with different compounds of
natural origin hoping to construct new hybrids with dual activity against cholinergic and …

A general approach towards the synthesis of tetrahydro-4 H-pyrazolo [1, 5-a][1, 4] diazepin-4-
one, tetrahydro [1, 4] diazepino [1, 2-a] indol-1-one and tetrahydro-1 H-benzo [4, 5] imidazo …

Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of
people worldwide characterized by cognitive decline and neurodegeneration. The …

Indoles and hydantoins are important heterocycles scaffolds which present in numerous
bioactive compounds which possess various biological activities. Moreover, they are …

The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

Neurodegeneration is a gradual decay process leading to the depletion of neurons in both
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …

Abstract Alzheimer's disease (AD), a relentless neurodegenerative disorder, is still waiting
for safer profile drugs, risk factors affecting AD's pathogenesis include aβ accumulation, tau …

The rise of antibiotic resistance and the decrease in the discovery of new antibiotics have
caused a global health crisis. Of particular concern is the fact that despite efforts to develop …