TFCP2/TFCP2L1/UBP1 transcription factors in cancer

G Kotarba, E Krzywinska, AI Grabowska, A Taracha… - Cancer letters, 2018 - Elsevier
The TFCP2/Grainyhead family of transcription factors is divided into two distinct subfamilies,
one of which includes the Grainyhead-like 1-3 (GRHL1-3) proteins and the other consists of …

The urothelial gene regulatory network: understanding biology to improve bladder cancer management

M Ramal, S Corral, M Kalisz, E Lapi, FX Real - Oncogene, 2024 - nature.com
The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

Unexpected Repertoire of Metazoan Transcription Factors in the Unicellular Holozoan Capsaspora owczarzaki

A Sebé-Pedrós, A de Mendoza, BF Lang… - Molecular biology …, 2011 - academic.oup.com
How animals (metazoans) originated from their single-celled ancestors remains a major
question in biology. As transcriptional regulation is crucial to animal development …

Roles of Grainyhead-like transcription factors in cancer

SM Frisch, JC Farris, PM Pifer - Oncogene, 2017 - nature.com
The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

Large-scale transcriptome sequencing in broiler chickens to identify candidate genes for breast muscle weight and intramuscular fat content

H Kang, D Zhao, H Xiang, J Li, G Zhao, H Li - Genetics Selection Evolution, 2021 - Springer
Background In broiler production, breast muscle weight and intramuscular fat (IMF) content
are important economic traits. Understanding the genetic mechanisms that underlie these …

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family

Q Ming, Y Roske, A Schuetz, K Walentin… - Nucleic acids …, 2018 - academic.oup.com
Abstract Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular
organisms as key regulators of epithelial differentiation, organ development and skin barrier …

Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer

M Mlacki, A Kikulska, E Krzywinska… - Experimental …, 2015 - journals.sagepub.com
The Grainyhead-like (GRHL) family of transcription factors has three mammalian members,
which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and …

[HTML][HTML] The transcription factor LSF: a novel oncogene for hepatocellular carcinoma

PK Santhekadur, D Rajasekaran, A Siddiq… - American journal of …, 2012 - ncbi.nlm.nih.gov
The transcription factor LSF (Late SV40 Factor), also known as TFCP2, belongs to the
LSF/CP2 family related to Grainyhead family of proteins and is involved in many biological …

Neglected functions of TFCP2/TFCP2L1/UBP1 transcription factors may offer valuable insights into their mechanisms of action

A Taracha, G Kotarba, T Wilanowski - International journal of molecular …, 2018 - mdpi.com
In recent years, the TFCP2 (transcription factor cellular promoter 2)/TFCP2L1 (TFCP2-like
1)/UBP1 (upstream binding protein 1) subfamily of transcription factors has been attracting …

Pioneering the developmental frontier

ED Larson, AJ Marsh, MM Harrison - Molecular cell, 2021 - cell.com
Coordinated changes in gene expression allow a single fertilized oocyte to develop into a
complex multi-cellular organism. These changes in expression are controlled by …