[HTML][HTML] BH3-only proteins Noxa and Puma are key regulators of induced apoptosis
Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …
Physiological cell death is important for maintaining homeostasis and optimal biological …
Regulation of innate immune responses by cell death‐associated caspases during virus infection
Y Fang, K Peng - The FEBS Journal, 2022 - Wiley Online Library
Viruses are obligate intracellular pathogens that rely on cellular machinery for successful
replication and dissemination. The host cells encode a number of different strategies to …
replication and dissemination. The host cells encode a number of different strategies to …
[HTML][HTML] Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death
Cancer is a global public health concern that is characterized by the uncontrolled growth of
tumor cells. It is regarded as the subsequent cause of death after cardiovascular disease …
tumor cells. It is regarded as the subsequent cause of death after cardiovascular disease …
DNA binding and evaluation of anticancer activity in vitro and in vivo of iridium (III) polypyridyl complexes
Y Zhang, Y Zhou, H Zhang, L Tian, J Hao… - Journal of Inorganic …, 2021 - Elsevier
In this report, we synthesized three new iridium (III) complexes:[Ir (piq) 2 (apip)] PF 6 (Ir1,
piq= 1-phenylisoquinoline, apip= 2-aminophenyl-1H-imidazo [4, 5-f][1, 10] …
piq= 1-phenylisoquinoline, apip= 2-aminophenyl-1H-imidazo [4, 5-f][1, 10] …
Alternative translation contributes to the generation of a cytoplasmic subpopulation of the Junín virus nucleoprotein that inhibits caspase activation and innate …
L Bostedt, L Fénéant, A Leske, J Holzerland… - Journal of …, 2024 - Am Soc Microbiol
The highly pathogenic arenavirus, Junín virus (JUNV), expresses three truncated alternative
isoforms of its nucleoprotein (NP), ie, NP53kD, NP47kD, and NP40kD. While both NP47kD …
isoforms of its nucleoprotein (NP), ie, NP53kD, NP47kD, and NP40kD. While both NP47kD …
[HTML][HTML] A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells
T Zhao, Q He, S Xie, H Zhan, C Jiang, S Lin, F Liu… - Molecular …, 2023 - Springer
Background Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a
hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the …
hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the …
[HTML][HTML] Differences in viral RNA synthesis but not budding or entry contribute to the in vitro attenuation of reston virus compared to ebola virus
BS Bodmer, J Greßler, ML Schmidt, J Holzerland… - Microorganisms, 2020 - mdpi.com
Most filoviruses cause severe disease in humans. For example, Ebola virus (EBOV) is
responsible for the two most extensive outbreaks of filovirus disease to date, with case …
responsible for the two most extensive outbreaks of filovirus disease to date, with case …
Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways for Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future …
J Banerjee, S Samanta, R Ahmed… - Current Protein and …, 2023 - ingentaconnect.com
Nowadays, discovering an effective and safe anticancer medication is one of the major
challenges. Premature death due to the unidirectional toxicity of conventional therapy is …
challenges. Premature death due to the unidirectional toxicity of conventional therapy is …
Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic …
Q Zhou, J Yin, J Tan, S Li, C Jiang, Y He - Toxicology and Applied …, 2022 - Elsevier
Arsenic is a toxic metalloid vastly dispersed all over the occupational environments,
manifesting multiple adverse health issues related to apoptosis. PUMA (p53 up-regulated …
manifesting multiple adverse health issues related to apoptosis. PUMA (p53 up-regulated …
[HTML][HTML] Regulation of stress-activated kinases in response to Tacaribe virus infection and its implications for viral replication
Arenaviruses include important zoonotic pathogens that cause hemorrhagic fever (eg, Junín
virus; JUNV) as well as other viruses that are closely related but apathogenic (eg, Tacaribe …
virus; JUNV) as well as other viruses that are closely related but apathogenic (eg, Tacaribe …