[HTML][HTML] Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng - Molecular biology reports, 2020 - Springer
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
[HTML][HTML] Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
Epithelial-to-mesenchymal transition in thyroid cancer: a comprehensive review
H Shakib, S Rajabi, MH Dehghan, FJ Mashayekhi… - Endocrine, 2019 - Springer
The Metastatic progression of solid tumors, such as thyroid cancer is a complex process
which involves various factors. Current understanding on the role of epithelial …
which involves various factors. Current understanding on the role of epithelial …
[HTML][HTML] Gene expression profiling and protein analysis reveal suppression of the C-Myc oncogene and inhibition JAK/STAT and PI3K/AKT/mTOR signaling by …
Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance,
making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is …
making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is …
[HTML][HTML] Disulfiram/Cu Kills and Sensitizes BRAF-Mutant Thyroid Cancer Cells to BRAF Kinase Inhibitor by ROS-Dependently Relieving Feedback Activation of …
J Xie, J Liu, M Zhao, X Li, Y Wang, Y Zhao… - International Journal of …, 2023 - mdpi.com
BRAFV600E, the most common genetic alteration, has become a major therapeutic target in
thyroid cancer. Vemurafenib (PLX4032), a specific inhibitor of BRAFV600E kinase, exhibits …
thyroid cancer. Vemurafenib (PLX4032), a specific inhibitor of BRAFV600E kinase, exhibits …
T-box transcription factor 19 promotes hepatocellular carcinoma metastasis through upregulating EGFR and RAC1
X Ji, X Chen, B Zhang, M Xie, T Zhang, X Luo, D Liu… - Oncogene, 2022 - nature.com
The effect of targeted therapy for metastatic hepatocellular carcinoma (HCC) is still
unsatisfactory. Exploring the underlying mechanism of HCC metastasis is favorable to …
unsatisfactory. Exploring the underlying mechanism of HCC metastasis is favorable to …
T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and …
H Liu, M Song, X Sun, X Zhang, H Miao, Y Wang - Bioengineered, 2021 - Taylor & Francis
Cervical cancer (CC) is the fourth most common cancers among women worldwide. T-box
transcription factor 1 (TBX1), a member of the T-box family, has anti-tumor effects in some …
transcription factor 1 (TBX1), a member of the T-box family, has anti-tumor effects in some …
Impact of DNA methyltransferase inhibitor 5‐azacytidine on cardiac development of zebrafish in vivo and cardiomyocyte proliferation, apoptosis, and the homeostasis …
Q Yang, F Wu, F Wang, K Cai, Y Zhang… - Journal of cellular …, 2019 - Wiley Online Library
Cardiac development is a peculiar process involving coordinated cellular differentiation,
migration, proliferation, and apoptosis. DNA methylation plays a key role in genomic …
migration, proliferation, and apoptosis. DNA methylation plays a key role in genomic …
LncRNA TBX5-AS1 Regulates the Tumor Progression Through the PI3K/AKT Pathway in Non-Small Cell Lung Cancer
Q Qu, S Jiang, X Li - OncoTargets and therapy, 2020 - Taylor & Francis
Purpose Long non-coding RNAs (lncRNAs) have been reported to play important roles in
tumor biology. In this study, we aimed to investigate the effects of T-box transcription factor 5 …
tumor biology. In this study, we aimed to investigate the effects of T-box transcription factor 5 …
Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways
C Li, Q Wang, X Wang, G Li, S Shen, X Wei - European journal of …, 2019 - Elsevier
Gambogic acid (GA) is a potential anti-cancer compound that is extracted from the resin of
Garciania hanburyi. The present study was designed to evaluate the anti-metastatic effect of …
Garciania hanburyi. The present study was designed to evaluate the anti-metastatic effect of …