The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

The RNA-binding protein HuR in human cancer: A friend or foe?

X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

K Abdelmohsen, AC Panda, R Munk… - RNA biology, 2017 - Taylor & Francis
HuR influences gene expression programs and hence cellular phenotypes by binding to
hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular …

In vitro and in vivo RNA inhibition by CD9-HuR functionalized exosomes encapsulated with miRNA or CRISPR/dCas9

Z Li, X Zhou, M Wei, X Gao, L Zhao, R Shi, W Sun… - Nano …, 2018 - ACS Publications
In vitro and in vivo delivery of RNAs of interest holds promise for gene therapy. Recently,
exosomes are considered as a kind of rational vehicle for RNA delivery, especially miRNA …

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

CW Schultz, R Preet, T Dhir, DA Dixon… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression

Y Liang, H Wang, B Chen, Q Mao, W Xia… - … Therapy-Nucleic Acids, 2021 - cell.com
Aberrant expression of circular RNAs (circRNAs) is involved in cancer progression through
interaction with RNA-binding proteins (RBPs). Herein, we screened circRNA expression of …

m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin

D Liang, WJ Lin, M Ren, J Qiu, C Yang, X Wang, N Li… - Autophagy, 2022 - Taylor & Francis
Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in
diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in …

Regulation of senescence traits by MAPKs

C Anerillas, K Abdelmohsen, M Gorospe - Geroscience, 2020 - Springer
A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases

JL Napoli - Pharmacology & therapeutics, 2017 - Elsevier
Abstract Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and
FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and …

HuR as a molecular target for cancer therapeutics and immune-related disorders

M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …