Pursuing functional biomarkers in complex disease: Focus on pulmonary arterial hypertension

G Benincasa, C Napoli, J Loscalzo, BA Maron - American Heart Journal, 2023 - Elsevier
A major gap in diagnosis, classification, risk stratification, and prediction of therapeutic
response exists in pulmonary arterial hypertension (PAH), driven in part by a lack of …

[HTML][HTML] Novel insights in the clinical management of hyperimmune patients before and after transplantation

V Grimaldi, M Pagano, G Moccia, C Maiello… - Current Research in …, 2023 - Elsevier
Despite improvements in anti-Human Leucocyte Antigens antibody detection, identification,
and characterization offer a better in peri-operative management techniques, antibodies …

[HTML][HTML] Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection

O Bestard, J Augustine, A Wee, E Poggio… - American Journal of …, 2024 - Elsevier
The objective of this study was to validate the performance of Tutivia, a peripheral blood
gene expression signature, in predicting early acute rejection (AR) post–kidney transplant …

Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases

G Benincasa, R Suades, T Padró… - European Heart …, 2023 - academic.oup.com
Although bioinformatic methods gained a lot of attention in the latest years, their use in real-
world studies for primary and secondary prevention of atherosclerotic cardiovascular …

Lung transplantation: Current insights and outcomes

C Napoli, G Benincasa, A Fiorelli, MG Strozziero… - Transplant …, 2024 - Elsevier
Until now, the ability to predict or retard immune-mediated rejection events after lung
transplantation is still limited due to the lack of specific biomarkers. The pressing need …

[HTML][HTML] Monitoring of serological, cellular and genomic biomarkers in transplantation, computational prediction models and role of cell-free DNA in transplant outcome

V Jimenez-Coll, S Llorente, F Boix, R Alfaro… - International Journal of …, 2023 - mdpi.com
The process and evolution of an organ transplant procedure has evolved in terms of the
prevention of immunological rejection with the improvement in the determination of immune …