The role of progesterone signaling in the pathogenesis of uterine leiomyoma

JJ Kim, EC Sefton - Molecular and cellular endocrinology, 2012 - Elsevier
Uterine leiomyomas are benign tumors that originate from the myometrium. Evidence points
to ovarian steroid hormones, in particular, progesterone as major promoters of leiomyoma …

Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications

MB Moravek, P Yin, M Ono, JS Coon V… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is
thought to arise from the clonal expansion of a single myometrial smooth muscle cell …

The impact and management of fibroids for fertility: an evidence-based approach

XC Guo, JH Segars - Obstetrics and Gynecology Clinics, 2012 - obgyn.theclinics.com
Uterine fibroids, or leiomyoma, are benign tumors of the uterus that may cause severe pain,
bleeding, and infertility. 1 Fibroids affect a woman's quality of life, as well as her fertility and …

Medical treatment of uterine leiomyoma

M Sabry, A Al-Hendy - Reproductive sciences, 2012 - journals.sagepub.com
Uterine leiomyomas (also called myomata or fibroids) are the most common gynecologic
tumors in the United States. The prevalence of leiomyomas is at least 3 to 4 times higher …

Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference …

JH Segars, EC Parrott, JD Nagel… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Uterine fibroids are the most common gynecologic tumors in women of
reproductive age yet the etiology and pathogenesis of these lesions remain poorly …

Complication rates and effectiveness of uterine artery embolization in the treatment of symptomatic leiomyomas: a systematic review and meta-analysis

SS Toor, A Jaberi, DB Macdonald… - American Journal of …, 2012 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this meta-analysis was to determine the rates of major
complications, other associated adverse events, reintervention, and clinical improvement …

Outcome of uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for uterine fibroids: long-term results

V Froeling, K Meckelburg, NF Schreiter… - European journal of …, 2013 - Elsevier
Objectives To compare the long-term outcome after uterine artery embolization (UAE) versus
magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic …

Systematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids

SC Khaw, RA Anderson, M Lui - Reproductive biomedicine online, 2020 - Elsevier
The aim of this study was to compare pregnancy outcomes after medical (ulipristal acetate
[UPA]), surgical (myomectomy) and radiological (uterine artery embolization [UAE] or …

Uterine leiomyoma stem cells: linking progesterone to growth

SE Bulun, MB Moravek, P Yin, M Ono… - Seminars in …, 2015 - thieme-connect.com
Uterine leiomyomas (fibroids) represent the most common class of benign tumors in women.
Multiple leiomyomas usually arise from the uterus of a symptomatic woman. These tumors …

Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids

M Ali, A Al-Hendy - Biology of reproduction, 2017 - academic.oup.com
Uterine fibroids (UFs, AKA leiomyoma) are the most important benign neoplastic threat to
women's health, with costs up to hundreds of billions of health care dollars worldwide …