The purpose of this study is to explore the possibilities for the application of laser therapy in
medicine and dentistry by analyzing lasers' underlying mechanism of action on different …

Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Background Mesenchymal stem cell (MSC)-based tissue engineering plays a major role in
regenerative medicine. However, the efficiency of MSC transplantation and survival of …

Background Little is known about the implications of circRNAs in the effects of melatonin
(MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and …

Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new
bone formation and affects millions of women worldwide. Melatonin can improve bone …

Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and
disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs …

Melatonin is known for its regulation of circadian rhythm. Recently, studies have shown that
melatonin may have a positive effect on the skeleton. By increasing age, the melatonin …

Melatonin research has been experiencing hyper growth in the last two decades; this relates
to its numerous physiological functions including anti-inflammation, oncostasis, circadian …