The multiple functions of melatonin in regenerative medicine

M Majidinia, RJ Reiter, SK Shakouri, I Mohebbi… - Ageing research …, 2018 - Elsevier
Melatonin research has been experiencing hyper growth in the last two decades; this relates
to its numerous physiological functions including anti-inflammation, oncostasis, circadian …

Black phosphorus accelerates bone regeneration based on immunoregulation

M Qiu, N Tulufu, G Tang, W Ye, J Qi, L Deng… - Advanced …, 2024 - Wiley Online Library
A fundamental understanding of inflammation and tissue healing suggests that the precise
regulation of the inflammatory phase, both in terms of location and timing, is crucial for bone …

Biomaterial Scaffolds Made of Chemically Cross‐Linked Gelatin Microsphere Aggregates (C‐GMSs) Promote Vascularized Bone Regeneration

P Wang, X Meng, R Wang, W Yang… - Advanced …, 2022 - Wiley Online Library
Various scaffolding systems have been attempted to facilitate vascularization in tissue
engineering by optimizing biophysical properties (eg, vascular‐like structures, porous …

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining …

C Luo, Q Yang, Y Liu, S Zhou, J Jiang, RJ Reiter… - Free Radical Biology …, 2019 - Elsevier
Melatonin is a neurohormone associated with sleep and wakefulness and is mainly
produced by the pineal gland. Numerous physiological functions of melatonin have been …

Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression

Y Han, YM Kim, HS Kim, KY Lee - Scientific reports, 2017 - nature.com
Although the biological role of melatonin in osteogenic differentiation has been suggested,
the mechanism of osteoblast differentiation remains unclear. Thus, the present study …

Melatonin attenuates calcium deposition from vascular smooth muscle cells by activating mitochondrial fusion and mitophagy via an AMPK/OPA1 signaling pathway

WR Chen, YJ Zhou, JQ Yang, F Liu… - … medicine and cellular …, 2020 - Wiley Online Library
Mitochondrial fusion/mitophagy plays a role in cardiovascular calcification. Melatonin has
been shown to protect against cardiovascular disease. This study sought to explore whether …

MicroRNA‐92b‐5p modulates melatonin‐mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM‐1

Y Li, C Feng, M Gao, M Jin, T Liu… - Journal of Cellular …, 2019 - Wiley Online Library
Osteoporosis is closely associated with the dysfunction of bone metabolism, which is caused
by the imbalance between new bone formation and bone resorption. Osteogenic …

Melatonin attenuates vascular calcification by activating autophagy via an AMPK/mTOR/ULK1 signaling pathway

WR Chen, JQ Yang, F Liu, XQ Shen, YJ Zhou - Experimental Cell Research, 2020 - Elsevier
Melatonin has been demonstrated to protect against calcification in cyclosporine
nephrotoxicity. Autophagy may affect vascular calcification by inhibiting apoptosis and the …

The role of melatonin in bone regeneration: A review of involved signaling pathways

F Malakoti, F Zare, R Zarezadeh, AR Sadigh… - Biochimie, 2022 - Elsevier
Increasing bone resorption followed by decreasing bone mineralization are hallmarks of
bone degeneration, which mostly occurs in the elderly population and post-menopausal …

Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway

WR Chen, YJ Zhou, Y Sha, XP Wu… - Journal of cellular …, 2020 - Wiley Online Library
Mitochondrial fission plays a role in cardiovascular calcification. Melatonin has previously
been shown to protect against cardiovascular disease, so this study sought to explore …