Melatonin having therapeutic bone regenerating capacity in biomaterials

J Huang, Y Li, C He - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
Bone defects are usually treated with bone grafting. Several synthetic biomaterials have
emerged to replace autologous and allogeneic bone grafts, but there are still shortcomings …

Caffeine supplementation at birth, but not 8 to 12 h post-birth, increased 24 h pre-weaning mortality in piglets

TL Nowland, K Kind, ML Hebart, W van Wettere - animal, 2020 - cambridge.org
Pre-weaning mortality represents a major economic loss and welfare concern for the global
pork industry. Caffeine administration prior to, or after, parturition positively affects metabolic …

[HTML][HTML] Phenotype changes of subchondral plate osteoblasts based on a rat model of ovariectomy-induced osteoarthritis

A Jiang, S Gao, Z Zhao, Q Tan, S Sun… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Osteoarthritis (OA) is prevalent in postmenopausal women. Subchondral bone
in ovariectomized (OVX) rats might play a more important role in cartilage degeneration …

Mechanism of salutary effects of melatonin-mediated liver protection after trauma-hemorrhage: p38 MAPK-dependent iNOS/HIF-1α pathway

JT Hsu, PH Le, CJ Lin, TH Chen… - American Journal …, 2017 - journals.physiology.org
Although melatonin attenuates the increases in inflammatory mediators and reduces organ
injury during trauma-hemorrhage, the mechanisms remain unclear. This study explored …

Combination of Melatonin and Zoledronic Acid Suppressed the Giant Cell Tumor of Bone in vitro and in vivo

X Wang, P Su, Y Kang, C Xu, J Qiu, J Wu… - Frontiers in Cell and …, 2021 - frontiersin.org
Melatonin (Mlt) confers potential antitumor effects in various types of cancer. However, to the
best of our knowledge, the role of Mlt in the giant cell tumor of bone (GCTB) remains …

Melatonin has a stimulatory effect on osteoblasts by upregulating col-i and opn expression/secretion

K Dalla-Costa, FV Yurtsever, J Penteado… - Acta Odontologica …, 2020 - SciELO Argentina
Melatonin has a stimulatory effect on osteoblasts by upregulating COL-I and OPN
expression/secretion Page 1 125 Vol. 33 Nº 2 / 2020 / 125-134 ISSN 1852-4834 Acta Odontol …

Melatonin-medicated neural JNK3 up-regulation promotes ameloblastic mineralization

Q Ren, J Pan, Y Chen, Z Shen, Z Yang… - Frontiers in Cell and …, 2021 - frontiersin.org
Introduction: Melatonin, an endogenous neurohormone, modulates the biological circadian
rhythms of vertebrates. It functions have been reported in previous stomatological studies as …

Melatonin promotes heterotopic ossification through regulation of endothelial-mesenchymal transition in injured achilles tendons in rats

J Zhang, J Tang, J Liu, B Yan, B Yan… - Frontiers in Cell and …, 2021 - frontiersin.org
Although heterotopic ossification (HO) has been reported to be a common complication of
the posttraumatic healing process, the underlying mechanism remains unknown …

Melatonin-induced osteogenesis with methanol-annealed silk materials

D Çetin Altındal, EN James, DL Kaplan… - Journal of Bioactive …, 2019 - journals.sagepub.com
Melatonin, a hormone produced in the pineal gland, has been investigated for bone repair,
remodeling, osteoporosis, as well as osseointegration of the implants. In this study, different …

黄芪多糖对高糖环境下MC3T3-E1 细胞活性影响的研究

滕腾, 孙鑫, 张冉, 柳忠豪 - 牙体牙髓牙周病学杂志, 2015 - cqvip.com
目的:: 探讨高糖环境下黄芪多糖(伯恩) 对细胞MC3T3-E1 增殖, 分化和矿化的影响. 方法:
将MC3T3-E1 分别与含黄芪多糖浓度为5, 0.5, 0.05 mg/mL 的高糖培养基(分别为HDA 组, MDA …