[HTML][HTML] Acute graft-versus-host disease

F Malard, E Holler, BM Sandmaier, H Huang… - Nature Reviews …, 2023 - nature.com
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

[HTML][HTML] Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy

T Sauerer, GF Velázquez, C Schmid - Molecular Cancer, 2023 - Springer
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion
of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in …

Posttransplantation cyclophosphamide expands functional myeloid-derived suppressor cells and indirectly influences Tregs

RE Fletcher, NS Nunes, MT Patterson, N Vinod… - Blood …, 2023 - ashpublications.org
Posttransplantation cyclophosphamide (PTCy), given on days+ 3 and+ 4, reduces graft-
versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT), but …

[HTML][HTML] Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies

S Wang, X Zhao, S Wu, D Cui, Z Xu - Biomarker Research, 2023 - Springer
The immunosuppressive tumor microenvironment (TME) supports the development of
tumors and limits tumor immunotherapy, including hematological malignancies …

[HTML][HTML] Graft-versus-host disease modulation by innate T cells

Y Fang, Y Zhu, A Kramer, Y Chen, YR Li… - International Journal of …, 2023 - mdpi.com
Allogeneic cell therapies, defined by genetically mismatched transplantation, have the
potential to become a cost-effective solution for cell-based cancer immunotherapy. However …

[HTML][HTML] New perspectives on myeloid-derived suppressor cells and their emerging role in haematology

N Bizymi, AM Matthaiou, A Matheakakis… - Journal of Clinical …, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) are immature cells of myeloid origin that have
gained researchers' attention, as they constitute promising biomarkers and targets for novel …

Regulatory T cells in pathological cardiac hypertrophy: mechanisms and therapeutic potential

L Liu, J Hu, H Lei, H Qin, C Wang, Y Gui… - Cardiovascular Drugs and …, 2023 - Springer
Background Pathological cardiac hypertrophy is linked to immune-inflammatory injury, and
regulatory T cells (Tregs) play a crucial role in suppressing immune-inflammatory …

[HTML][HTML] Exosomes, MDSCs and Tregs: A new frontier for GVHD prevention and treatment

NJ Hess, JA Kink, P Hematti - Frontiers in Immunology, 2023 - frontiersin.org
The development of graft versus host disease (GVHD) represents a long-standing
complication of allogeneic hematopoietic cell transplantation (allo-HCT). Different …

[HTML][HTML] Myeloid-derived suppressor cells (MDSC) in the umbilical cord blood: biological significance and possible therapeutic applications

N Bizymi, A Georgopoulou, N Mastrogamvraki… - Journal of Clinical …, 2022 - mdpi.com
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of
myeloid cells that suppress immune responses in cancer, infection, and trauma. They mainly …

[HTML][HTML] Decreased circulating myeloid-derived suppressor cell count at the engraftment is one of the risk factors for multiple myeloma relapse after autologous …

T Tyrinova, E Batorov, T Aristova, G Ushakova… - Heliyon, 2024 - cell.com
Recent studies demonstrated that myeloid-derived suppressor cells (MDSCs) are involved
in the pathogenesis and progression of multiple myeloma (MM). Nevertheless, data on the …