Functional characterization of microRNA-27a-3p expression in human polycystic ovary syndrome

M Wang, J Sun, B Xu, M Chrusciel, J Gao… - …, 2018 - academic.oup.com
The goal of this study was to characterize the function of microRNA-27a-3p (miR-27a-3p) in
polycystic ovary syndrome (PCOS). miR-27a-3p expression was analyzed in excised …

The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in …

SY Ji, XM Liu, BT Li, YL Zhang, HB Liu… - MHR: Basic science …, 2017 - academic.oup.com
STUDY QUESTION What is the physiological function of Yes-associated protein-1 (Yap1), a
susceptibility gene for polycystic ovary syndrome (PCOS), in ovarian granulosa cells (GCs) …

Role of microRNA in the pathogenesis of polycystic ovary syndrome

Z Chen, H Ou, H Wu, P Wu, Z Mo - DNA and cell biology, 2019 - liebertpub.com
Polycystic ovary syndrome (PCOS) is the most typical metabolic syndrome in women of
reproductive age, with a high prevalence and an increased risk of long-term complications …

[HTML][HTML] The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARγ …

MJ Chen, CH Chou, SU Chen, WS Yang, YS Yang… - Scientific reports, 2015 - nature.com
Intraovarian hyperandrogenism is one of the determining factors of follicular arrest in women
with polycystic ovary syndrome (PCOS). Using androgenized rat models, we investigated …

[HTML][HTML] Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum …

CU Chern, KH Tsui, SG Vitale, SN Chen… - Reproductive Biology …, 2018 - Springer
Background Dehydroepiandrosterone (DHEA) is now widely used as an adjuvant for in vitro
fertilization (IVF) cycles in poor ovarian responders (PORs). Several studies showed that …

Dysregulation of steroid metabolome in follicular fluid links phthalate exposure to diminished ovarian reserve of childbearing-age women

Y Li, N Xiao, M Liu, Y Liu, A He, L Wang, H Luo… - Environmental …, 2023 - Elsevier
The widespread use of phthalates (PAEs) has drawn increasing attention due to their
endocrine disruption and reproductive toxicity, while the steroid metabolome is essential for …

[HTML][HTML] NORFA, long intergenic noncoding RNA, maintains sow fertility by inhibiting granulosa cell death

X Du, L Liu, Q Li, L Zhang, Z Pan, Q Li - Communications Biology, 2020 - nature.com
Long intergenic non-coding RNAs (lincRNAs) have been proved to be involved in regulating
female reproduction. However, to what extent lincRNAs are involved in ovarian functions …

[HTML][HTML] Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function

G Yu, D Zhang, W Liu, J Wang, X Liu, C Zhou, J Gui… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The androgen receptor (AR) is a nuclear receptor protein family member and inducible
transcription factor that modulates androgen target gene expression. Studies using a mouse …

Revisiting the physiological role of androgens in women

E Rosato, F Sciarra, E Anastasiadou… - Expert Review of …, 2022 - Taylor & Francis
Introduction Extensive research underlines the critical functions of androgens in females.
Nevertheless, the precise mechanisms of their action are poorly understood. Here, we …

miR-1275 controls granulosa cell apoptosis and estradiol synthesis by impairing LRH-1/CYP19A1 axis

J Liu, X Li, Y Yao, Q Li, Z Pan, Q Li - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Abstract miR-1275 is one of the microRNAs (miRNAs) that are differentially expressed
during follicular atresia in pig ovaries, as identified by a miRNA microarray assay in our …