A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model
Polycystic ovary syndrome (PCOS) is a common cause of female infertility.
Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the …
Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the …
MicroRNAs related to androgen metabolism and polycystic ovary syndrome
AE Sørensen, PB Udesen, ML Wissing… - Chemico-biological …, 2016 - Elsevier
Polycystic ovary syndrome (PCOS) is a frequent endocrine disorder in women. PCOS is
associated with altered features of androgen metabolism, increased insulin resistance and …
associated with altered features of androgen metabolism, increased insulin resistance and …
Leptin-induced CART (cocaine-and amphetamine-regulated transcript) is a novel intraovarian mediator of obesity-related infertility in females
Obesity is considered detrimental to women's reproductive health. Although most of the
attention has been focused on the effects of obesity on hypothalamic function, studies …
attention has been focused on the effects of obesity on hypothalamic function, studies …
Partially purified non-polar phytocomponents from Aloe barbadensis Mill. gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary …
Abstract Ethnopharmacological relevance In India, Kumaryasava, a popular Aloe
barbadensis Mill. gel preparation has therapeutic value in treatment of female reproductive …
barbadensis Mill. gel preparation has therapeutic value in treatment of female reproductive …
MicroRNAs and long non-coding RNAs and their hormone-like activities in cancer
B Pardini, GA Calin - Cancers, 2019 - mdpi.com
Hormones are messengers circulating in the body that interact with specific receptors on the
cell membrane or inside the cells and regulate, at a distal site, the activities of specific target …
cell membrane or inside the cells and regulate, at a distal site, the activities of specific target …
Short-term testosterone use in female mice does not impair fertilizability of eggs: implications for the fertility care of transgender males
CB Bartels, TF Uliasz, L Lestz… - Human …, 2021 - academic.oup.com
STUDY QUESTION Does testosterone use in females affect reproductive potential,
particularly with regard to the production of fertilizable gametes? SUMMARY ANSWER …
particularly with regard to the production of fertilizable gametes? SUMMARY ANSWER …
Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome
Z Ma, H Zhao, Y Zhang, X Liu, C Hao - Archives of Gynecology and …, 2019 - Springer
Abstract Purpose Circular RNAs (circRNAs) mediate the posttranscriptional regulation of
multiple genes by functioning as microRNA (miRNA) sponges. This study aimed to detect …
multiple genes by functioning as microRNA (miRNA) sponges. This study aimed to detect …
Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases
O Tšuiko, M Noukas, O Žilina, K Hensen… - Human …, 2016 - academic.oup.com
STUDY QUESTION Can spontaneous premature ovarian failure (POF) patients derived from
population-based biobanks reveal the association between copy number variations (CNVs) …
population-based biobanks reveal the association between copy number variations (CNVs) …
Paxillin knockout in mouse granulosa cells increases fecundity
K Vann, AE Weidner, AC Walczyk… - Biology of …, 2023 - academic.oup.com
Paxillin is an intracellular adaptor protein involved in focal adhesions, cell response to
stress, steroid signaling, and apoptosis in reproductive tissues. To investigate the role of …
stress, steroid signaling, and apoptosis in reproductive tissues. To investigate the role of …
Altered theca and cumulus oocyte complex gene expression, follicular arrest and reduced fertility in cows with dominant follicle follicular fluid androgen excess
AF Summers, WE Pohlmeier, KM Sargent, BD Cole… - PloS one, 2014 - journals.plos.org
Aspiration of bovine follicles 12–36 hours after induced corpus luteum lysis serendipitously
identified two populations of cows, one with High androstenedione (A4;> 40 ng/ml; mean …
identified two populations of cows, one with High androstenedione (A4;> 40 ng/ml; mean …