Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

Background The efficacy of vaginal progesterone for preventing preterm birth and adverse
perinatal outcomes in singleton gestations with a short cervix has been questioned after …

The microbiome of the female reproductive tract defies the convention that high biodiversity
is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous …

Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

Regulatory T cells (Tregs) have been exhaustively investigated during early pregnancy;
however, their role later in gestation is poorly understood. Herein, we report that functional …

Spontaneous preterm birth (PTB) and preterm pre-labor rupture of the membranes (pPROM)
are major pregnancy complications. Although PTB and pPROM have common etiologies …

Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

The cervix is the essential gatekeeper for birth. Incomplete cervix remodeling contributes to
problems with delivery at or post-term while preterm birth is a major factor in perinatal …

Intra-amniotic inflammation is strongly associated with spontaneous preterm labor and birth,
the leading cause of perinatal mortality and morbidity worldwide. Previous studies have …

The central role of inflammatory processes in labour and delivery is now well-recognised.
However, the biomolecular, immunological and endocrine mechanisms involved in the …