A biophysical perspective on the resilience of neuronal excitability across timescales
Neuronal membrane excitability must be resilient to perturbations that can take place over
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …
[HTML][HTML] Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
J Wu, IH Quraishi, Y Zhang, M Bromwich… - Cell reports, 2024 - cell.com
The KCNT1 gene encodes the sodium-activated potassium channel Slack (KCNT1, K Na
1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans cause cortical …
1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans cause cortical …