Targeting metalloenzymes for therapeutic intervention

AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Angiotensin-I-converting enzyme and its relatives

JF Riordan - Genome biology, 2003 - Springer
Angiotensin-I-converting enzyme (ACE) is a monomeric, membrane-bound, zinc-and
chloride-dependent peptidyl dipeptidase that catalyzes the conversion of the decapeptide …

2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertension

HY Lee, J Shin, GH Kim, S Park, SH Ihm, HC Kim… - Clinical …, 2019 - Springer
The standardized techniques of blood pressure (BP) measurement in the clinic are
emphasized and it is recommended to replace the mercury sphygmomanometer by a non …

Ace revisited: a new target for structure-based drug design

KR Acharya, ED Sturrock, JF Riordan… - Nature Reviews Drug …, 2003 - nature.com
Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …

Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease

CM Ferrario, AE Mullick - Pharmacological research, 2017 - Elsevier
A collective century of discoveries establishes the importance of the renin angiotensin
aldosterone system in maintaining blood pressure, fluid volume and electrolyte homeostasis …

[HTML][HTML] Angiotensin-converting enzyme inhibitors induce cough

İ Yılmaz - Turkish thoracic journal, 2019 - ncbi.nlm.nih.gov
Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as
hypertension, congestive heart failure, and myocardial infarction. Although these drugs are …

Angiotensin-converting enzyme inhibitor-induced angioedema

S Bezalel, K Mahlab-Guri, I Asher, B Werner… - The American journal of …, 2015 - Elsevier
Angiotensin-converting enzyme inhibitors (ACE-I) are widely used, effective, and well-
tolerated antihypertensive agents. The mechanisms by which those agents act can cause …

High angiotensin-I converting enzyme (ACE) inhibitory activity of Alcalase-digested green soybean (Glycine max) hydrolysates

MA Hanafi, SN Hashim, SY Chay… - Food Research …, 2018 - Elsevier
As a protein-rich, underutilized crop, green soybean could be exploited to produce
hydrolysates containing angiotensin-I converting enzyme (ACE) inhibitory peptides. Defatted …

2013 Korean Society of Hypertension guidelines for the management of hypertension. Part II—treatments of hypertension

J Shin, JB Park, K Kim, JH Kim, DH Yang, WB Pyun… - Clinical …, 2015 - Springer
Abstract Treatment strategies are provided in accordance with the level of global
cardiovascular risk, from lifestyle modification in the lower risk group to more comprehensive …

Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review

S Alshahrani - Frontiers in Pharmacology, 2023 - frontiersin.org
Chronic kidney disease presents a health challenge that has a complex underlying
pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options …