Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …

Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections.
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …

Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks,
leading to cell lethality. To understand the molecular mechanisms underlying this process …

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1.
We here investigated fork progression and chromosomal breakage in human cells in …