The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

The human gut microbiome is a huge microbial community that plays an irreplaceable role
in human life. With the further development of research, the influence of intestinal flora on …

The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …

Over the past decade, the gut microbiota has emerged as a key component in regulating
brain processes and behavior. Diet is one of the major factors involved in shaping the gut …

Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However,
how microbiota-derived metabolites, eg, butyrate, regulate functions of neutrophils in the …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Abstract Diurnal (ie., 24-hour) oscillations of the gut microbiome have been described in
various species including mice and humans. However, the driving force behind these …

The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate
by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by …

Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …