Therapeutic vaccines for tuberculosis: an overview

R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …

The status of tuberculosis vaccine development

LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …

The tuberculous granuloma and preexisting immunity

SB Cohen, BH Gern, KB Urdahl - Annual review of immunology, 2022 - annualreviews.org
Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …

[HTML][HTML] Emerging vaccine nanotechnology: from defense against infection to sniping cancer

C Feng, Y Li, BE Ferdows, DN Patel, J Ouyang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Looking retrospectively at the development of humanity, vaccination is an unprecedented
medical landmark that saves lives by harnessing the human immune system. During the …

Tuberculosis vaccine: A journey from BCG to present

S Fatima, A Kumari, G Das, VP Dwivedi - Life sciences, 2020 - Elsevier
Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease,
causing around 1.6 million deaths each year. This situation has become more complicated …

Nutritional supplementation to prevent tuberculosis incidence in household contacts of patients with pulmonary tuberculosis in India (RATIONS): a field-based, open …

A Bhargava, M Bhargava, A Meher, A Benedetti… - The Lancet, 2023 - thelancet.com
Summary Background In India, tuberculosis and undernutrition are syndemics with a high
burden of tuberculosis coexisting with a high burden of undernutrition in patients and in the …

Novel vaccine technologies for the 21st century

JR Mascola, AS Fauci - Nature Reviews Immunology, 2020 - nature.com
Novel approaches to vaccine development include structure-based immunogen design,
gene-based vaccine platforms and formulation of recombinant antigens with potent …

Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

JS Woodworth, HS Clemmensen, H Battey… - Nature …, 2021 - nature.com
Given the encouraging clinical results of both candidate subunit vaccines and revaccination
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …

Vaccinology in the post− COVID-19 era

R Rappuoli, E De Gregorio… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic is a shocking reminder of how our world would look in the
absence of vaccination. Fortunately, new technologies, the pace of understanding new and …