Background An estimated one fourth of the world's population is infected with
Mycobacterium tuberculosis, and 5–10% of those infected develop tuberculosis in their …

Immunotherapies are disease management strategies that target or manipulate components
of the immune system. Infectious diseases pose a significant threat to human health as …

Energy metabolism is a universal process occurring in all life forms. In Mycobacterium
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …

Background: Tuberculosis (TB) is an old infectious disease caused by Mycobacterium
tuberculosis infection. Vaccination is the most effective way to prevent and control TB …

More effective tuberculosis vaccines are needed to help reach World Health Organization
tuberculosis elimination goals. Insufficient evidence exists on the potential impact of future …

Recent data from mice and non-human primate models of tuberculosis suggested that
CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis …

Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each
year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is …

ABSTRACT Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against
tuberculosis (TB). However, BCG has variable efficacy and cannot completely prevent TB …

Abstract The M72/AS01E tuberculosis vaccine showed 50%(95% CI: 2–74%) efficacy in a
phase 2B trial in preventing active pulmonary tuberculosis disease, but potential cost …

Dendritic cells (DCs) are principal defense components that play multifactorial roles in
translating innate immune responses to adaptive immunity in Mycobacterium tuberculosis …