The diversity outbred mouse population is an improved animal model of vaccination against tuberculosis that reflects heterogeneity of protection

SL Kurtz, AP Rossi, GL Beamer, DM Gatti, I Kramnik… - Msphere, 2020 - Am Soc Microbiol
Many studies of Mycobacterium tuberculosis infection and immunity have used mouse
models. However, outcomes of vaccination and challenge with M. tuberculosis in inbred …

A tuberculosis epidemic model as a proxy for the assessment of the novel M72/AS01E vaccine

D Aldila, JP Chávez, KP Wijaya, NC Ganegoda… - … in Nonlinear Science …, 2023 - Elsevier
Tuberculosis (TB) is a bacterial infectious disease that comes with a high mortality rate
through manifesting lung damage. Understanding the TB transmission is critical to designing …

[HTML][HTML] Tuberculosis vaccines in the era of Covid-19–what is taking us so long?

HM Dockrell, H McShane - EBioMedicine, 2022 - thelancet.com
The Mycobacterium bovis BCG vaccine was first used in 1921, but has not controlled the
global spread of tuberculosis (TB). There are still no new licensed tuberculosis vaccines …

New tuberculosis vaccines: advances in clinical development and modelling

CK Weerasuriya, RA Clark, RG White… - Journal of internal …, 2020 - Wiley Online Library
Tuberculosis remains a major source of morbidity and mortality worldwide, with 10 million
cases and 1.5 million deaths in 2018. Achieving 'End TB'prevention and care goals by 2035 …

[HTML][HTML] Towards new TB vaccines

B Brazier, H McShane - Seminars in immunopathology, 2020 - Springer
Mycobacterium tuberculosis remains the leading cause of death attributed to a single
infectious organism. Bacillus Calmette-Guerin (BCG), the standard vaccine against M …

[HTML][HTML] A Structural View at Vaccine Development against M. tuberculosis

M Romano, F Squeglia, E Kramarska, G Barra… - Cells, 2023 - mdpi.com
Tuberculosis (TB) is still the leading global cause of death from an infectious bacterial agent.
Limiting tuberculosis epidemic spread is therefore an urgent global public health priority. As …

HIV-Associated Tuberculosis

G Meintjes, G Maartens - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points HIV-Associated Tuberculosis Almost half of inpatients with human
immunodeficiency virus (HIV)–associated tuberculosis in countries with a high disease …

Estimation of the global burden of Mycobacterium tuberculosis lineage 1

T Netikul, P Palittapongarnpim… - Infection, Genetics and …, 2021 - Elsevier
Tuberculosis is still problematic as it affects large numbers of people globally.
Mycobacterium tuberculosis Lineage 1 (L1) or Indo Oceanic Lineage, one of widespread …

[HTML][HTML] Management of latent tuberculosis infection in China: Exploring solutions suitable for high-burden countries

X Cui, L Gao, B Cao - International Journal of Infectious Diseases, 2020 - Elsevier
China is one of the countries with a high burden of tuberculosis (TB) and latent tuberculosis
infection (LTBI). It was recently estimated that China had the highest LTBI burden in the …

[HTML][HTML] Leveraging antibody, B cell and Fc receptor interactions to understand heterogeneous immune responses in tuberculosis

SM Carpenter, LL Lu - Frontiers in immunology, 2022 - frontiersin.org
Despite over a century of research, Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis (TB), continues to kill 1.5 million people annually. Though less than 10% of …