[HTML][HTML] Epigenetic alterations in cancer
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
Molecular control of activation and priming in macrophages
In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory
signals of local or systemic origin that influence their basal functions and responses to …
signals of local or systemic origin that influence their basal functions and responses to …
The pioneer transcription factor FoxA maintains an accessible nucleosome configuration at enhancers for tissue-specific gene activation
M Iwafuchi-Doi, G Donahue, A Kakumanu, JA Watts… - Molecular cell, 2016 - cell.com
Nuclear DNA wraps around core histones to form nucleosomes, which restricts the binding
of transcription factors to gene regulatory sequences. Pioneer transcription factors can bind …
of transcription factors to gene regulatory sequences. Pioneer transcription factors can bind …
Structures of+ 1 nucleosome–bound PIC-Mediator complex
RNA polymerase II–mediated eukaryotic transcription starts with the assembly of the
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
Post-translational modifications of histones that influence nucleosome dynamics
GD Bowman, MG Poirier - Chemical reviews, 2014 - ACS Publications
Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
MA Horlbeck, LB Witkowsky, B Guglielmi, JM Replogle… - elife, 2016 - elifesciences.org
The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated
protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating …
protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating …
The impact of short tandem repeat variation on gene expression
SF Fotsing, J Margoliash, C Wang, S Saini, R Yanicky… - Nature …, 2019 - nature.com
Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans.
However, genome-wide studies of the effects of STRs on gene expression thus far have had …
However, genome-wide studies of the effects of STRs on gene expression thus far have had …
Structures of transcription preinitiation complex engaged with the+ 1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
Latent enhancers activated by stimulation in differentiated cells
According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …
repertoire is completely established and maintained by cooperatively acting lineage-specific …
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
K Luger, ML Dechassa, DJ Tremethick - Nature reviews Molecular cell …, 2012 - nature.com
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …