Shiga toxin-encoding bacteriophages–genomes in motion

S Herold, H Karch, H Schmidt - International journal of medical …, 2004 - Elsevier
Shiga toxins (Stx) represent a group of bacterial toxins that are involved in human and
animal disease. Stx are mainly produced by Escherichia coli isolated from human and non …

Genome evolution in major Escherichia coli O157:H7 lineages

Y Zhang, C Laing, M Steele, K Ziebell, R Johnson… - BMC genomics, 2007 - Springer
Abstract Background Genetic analysis of Escherichia coli O157: H7 strains has shown
divergence into two distinct lineages, lineages I and II, that appear to have distinct ecological …

Identification of Common Subpopulations of Non-Sorbitol-Fermenting, β-Glucuronidase-Negative Escherichia coli O157:H7 from Bovine Production Environments …

Z Yang, J Kovar, J Kim, J Nietfeldt… - Applied and …, 2004 - Am Soc Microbiol
ABSTRACT Non-sorbitol-fermenting, β-glucuronidase-negative Escherichia coli O157: H7
strains are regarded as a clone complex, and populations from different geographical …

Comparative genomics of Shiga toxin encoding bacteriophages

DL Smith, DJ Rooks, PCM Fogg, AC Darby… - BMC genomics, 2012 - Springer
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin
genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause …

Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms

T Shimizu, Y Ohta, M Noda - Infection and immunity, 2009 - Am Soc Microbiol
ABSTRACT Shiga toxin 1 (Stx1) is located in the periplasmic fraction, while Stx2 is found in
the extracellular fraction, suggesting that enterohemorrhagic Escherichia coli (EHEC) …

Rifaximin Does Not Induce Toxin Production or Phage-Mediated Lysis of Shiga Toxin-Producing Escherichia coli

TJ Ochoa, J Chen, CM Walker… - Antimicrobial Agents …, 2007 - Am Soc Microbiol
Diarrhea in children is often caused by enteropathogen infections that might benefit from
early empirical antibiotic therapy. However, when the definition of the pathogen requires …

Everything at once: comparative analysis of the genomes of bacterial pathogens

CR Laing, Y Zhang, JE Thomas, VPJ Gannon - Veterinary microbiology, 2011 - Elsevier
The sum of unique genes in all genomes of a bacterial species is referred to as the pan-
genome and is comprised of variably absent or present accessory genes and universally …

A Comparison of Shiga-Toxin 2 Bacteriophage from Classical Enterohemorrhagic Escherichia coli Serotypes and the German E. coli O104:H4 Outbreak Strain

CR Laing, Y Zhang, MW Gilmour, V Allen, R Johnson… - PloS one, 2012 - journals.plos.org
Escherichia coli O104: H4 was associated with a severe foodborne disease outbreak
originating in Germany in May 2011. More than 4000 illnesses and 50 deaths were reported …

An inducible lambdoid prophage encoding cytolethal distending toxin (Cdt-I) and a type III effector protein in enteropathogenic Escherichia coli

M Asakura, A Hinenoya, MS Alam… - Proceedings of the …, 2007 - National Acad Sciences
Cytolethal distending toxins (CDTs) are inhibitory cyclomodulins, which block eukaryotic cell
proliferation and are produced by a diverse group of Gram-negative bacteria, including …

Collagen-Like Proteins in Pathogenic E. coli Strains

N Ghosh, TJ McKillop, TA Jowitt, M Howard, H Davies… - PloS one, 2012 - journals.plos.org
The genome sequences of enterohaemorrhagic E. coli O157: H7 strains show multiple open-
reading frames with collagen-like sequences that are absent from the common laboratory …