Under normal conditions, inflammation is a protective and physiological response to various
harmful stimuli. However, in several chronic debilitating disorders, such as chronic kidney …

Protein-energy wasting (PEW), a term proposed by the International Society of Renal
Nutrition and Metabolism (ISRNM), refers to the multiple nutritional and catabolic alterations …

The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring
trophic and protective functions. Since the biochemical environment shapes the structure …

Elevated protein catabolism and protein malnutrition are common in patients with chronic
kidney disease (CKD) and end-stage renal disease (ESRD). The underlying etiology …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …

Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …

Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are associated with
systemic inflammation and acquired immunodeficiency, which promote cardiovascular …

Systemic inflammation in end-stage renal disease is an established risk factor for mortality
and a catalyst for other complications, which are related to a premature aging phenotype …

CKD associates with systemic inflammation, but the underlying cause is unknown. Here, we
investigated the involvement of intestinal microbiota. We report that collagen type 4 α3 …