Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

Cardiovascular calcification, including vascular calcification and calcific aortic valve disease
(CAVD), is a serious worldwide health problem, especially in older adults. The mechanisms …

Introduction: Fibroblasts are mesenchymal cells that predominantly produce and maintain
the extracellular matrix (ECM) and are critical mediators of injury response. In the heart …

Pseudoxanthoma elasticum (PXE) is a rare disease characterized by ectopic calcification,
however, despite the widely spread effect of pro/anti-calcifying systemic factors associated …

Cardiovascular diseases are the number one cause of death globally. The most important
determinant of cardiovascular health is a person's age. Aging results in structural changes …

Understanding the molecular mechanism by which the periodontal ligament (PDL) is
maintained uncalcified between two mineralized tissues (cementum and bone) may facilitate …

Calcification is a process of accumulation of calcium in tissues and deposition of calcium
salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the …

Vascular calcification (VC) is a common pathological change in many chronic diseases,
such as diabetes and chronic kidney disease. It is mainly deposited in the intima and media …

Human cytomegalovirus (HCMV) is a widespread pathogen that causes lifelong latent
infection in the majority of the world population. HCMV is associated with increased …

Cardiac calcification is a crucial but underrecognized pathological process, greatly
increasing the risk of cardiovascular diseases. Little is known about how cardiac fibroblasts …