Objective: Gastric cancer is one of the leading causes of death worldwide, with many
influences contributing to the disease. The aim of this study was to identify the most …

A multifactorial and multistep model of gastric cancer (GC) is currently accepted, according
to which different environmental and genetic factors are involved at different stages in the …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Abstract Objective Bisphenol A (BPA), a common endocrine disrupter, can be activated by
cytochrome P450 (CYP) metabolizing enzymes and might influence the development of …

Polycyclic aromatic hydrocarbons (PAH) and tobacco‐specific nitrosamines (TSNA)
metabolism‐related genes play an important role in the development of cancers. We …

E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin–
proteasome system, together with ubiquitin activating enzyme E1 and ubiquitin-conjugating …

Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of
various human diseases, such as endometriosis and cancers arising from the breast and …

Androgens, estrogens, progesterone and related signals are reported to be involved in the
pathology of gastric cancer. However, varied conclusions exist based on serum hormone …

Acute lymphoblastic leukemia (ALL) is a malignant tumor common in children. Studies of
genetic susceptibility to cancer using biallelic insertion/deletion (INDEL) type polymorphisms …

Background The dysregulation of gut microbiota is pivotal in colorectal carcinogenesis.
Meanwhile, altered gut microbiome may affect the development of intestinal diseases …