Drug delivery systems in regenerative medicine: an updated review

A Mansour, M Romani, AB Acharya, B Rahman… - Pharmaceutics, 2023 - mdpi.com
Modern drug discovery methods led to evolving new agents with significant therapeutic
potential. However, their properties, such as solubility and administration-related …

Temporomandibular joint osteoarthritis: pathogenic mechanisms involving the cartilage and subchondral bone, and potential therapeutic strategies for joint …

A Cardoneanu, LA Macovei, AM Burlui… - International Journal of …, 2022 - mdpi.com
The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the
movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc …

Harnessing stem cell-derived extracellular vesicles for the regeneration of degenerative bone conditions

Z Jia, S Zhang, W Li - International Journal of Nanomedicine, 2023 - Taylor & Francis
Degenerative bone disorders such as intervertebral disc degeneration (IVDD), osteoarthritis
(OA), and osteoporosis (OP) pose significant health challenges for aging populations and …

Extracellular Vesicles in Atherosclerosis: State of the Art

W Olejarz, K Sadowski, K Radoszkiewicz - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in the
arteries, leading to narrowing and thrombosis that causes mortality. Emerging evidence has …

[HTML][HTML] Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: from mechanisms to therapy

Y Pan, W Wu, X Jiang, Y Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and
have high morbidity and mortality worldwide, as well as substantial health and economic …

Extracellular vesicles as a translational approach for the treatment of COVID-19 disease: an updated overview

E Serretiello, A Ballini, A Smimmo, M Acunzo, M Raimo… - Viruses, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic
in the years 2020–2022. With a high prevalence, an easy route of transmission, and a long …

Extracellular vesicles for dental pulp and periodontal regeneration

H Lai, J Li, X Kou, X Mao, W Zhao, L Ma - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles (EVs) are lipid bound particles derived from their original cells, which
play critical roles in intercellular communication through their cargoes, including protein …

Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS …

X Jiang, J Yang, Y Lin, F Liu, J Tao, W Zhang… - Stem Cell Research & …, 2023 - Springer
Background Acute compartment syndrome (ACS) is one of the most common complications
of musculoskeletal injury, leading to the necrosis and demise of skeletal muscle cells. Our …

Advances in purification, modification, and application of extracellular vesicles for novel clinical treatments

Y Matsuzaka, R Yashiro - Membranes, 2022 - mdpi.com
Extracellular vesicles (EV) are membrane vesicles surrounded by a lipid bilayer membrane
and include microvesicles, apoptotic bodies, exosomes, and exomeres. Exosome …

A review on the current literature regarding the value of exosome miRNAs in various diseases

S Li, D Lv, H Yang, Y Lu, Y Jia - Annals of Medicine, 2023 - Taylor & Francis
Abstract Objective: Exosome microRNAs (miRNAs) have great research outlook in clinical
therapy and biomarkers, they have been found to have a close to multiple diseases. A …