Clinical implementation of pharmacogenomics for personalized precision medicine: barriers and solutions
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …
improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based …
Genetics and biomarkers in personalisation of lung cancer treatment
R Rosell, TG Bivona, N Karachaliou - The Lancet, 2013 - thelancet.com
Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …
Applying next-generation sequencing platforms for pharmacogenomic testing in clinical practice
Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy.
Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical …
Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical …
Big data and the precision medicine revolution
The big data revolution is making vast amounts of information available in all sectors of the
economy including health care. One important type of data that is particularly relevant to …
economy including health care. One important type of data that is particularly relevant to …
Pharmacogenetic testing: a tool for personalized drug therapy optimization
KA Malsagova, TV Butkova, AT Kopylov, AA Izotov… - Pharmaceutics, 2020 - mdpi.com
Pharmacogenomics is a study of how the genome background is associated with drug
resistance and how therapy strategy can be modified for a certain person to achieve benefit …
resistance and how therapy strategy can be modified for a certain person to achieve benefit …
[HTML][HTML] Preemptive pharmacogenetic testing: exploring the knowledge and perspectives of US payers
NJ Keeling, MM Rosenthal, D West-Strum, AS Patel… - Genetics in …, 2019 - Elsevier
Purpose Preemptive pharmacogenetic testing aims to optimize medication use by having
genetic information at the point of prescribing. Payers' decisions influence implementation of …
genetic information at the point of prescribing. Payers' decisions influence implementation of …
Pharmacogenomics in stroke and cardiovascular disease: state of the art
There is considerable interindividual variability in the response to antiplatelet and
anticoagulant therapies, and this variation may be attributable to genetic variants. There has …
anticoagulant therapies, and this variation may be attributable to genetic variants. There has …
Unveiling the guidance heterogeneity for genome-informed drug treatment interventions among regulatory bodies and research consortia
S Koutsilieri, F Tzioufa, DC Sismanoglou… - Pharmacological …, 2020 - Elsevier
Pharmacogenomics and personalized medicine interventions hold promise to optimize drug
treatment modalities and hence, improve the quality of life of the patients by minimizing the …
treatment modalities and hence, improve the quality of life of the patients by minimizing the …
Assessment of patient perceptions of genomic testing to inform pharmacogenomic implementation
YM Lee, RP McKillip, BA Borden… - Pharmacogenetics …, 2017 - journals.lww.com
Objective Pharmacogenomics seeks to improve prescribing by reducing drug
inefficacy/toxicity. However, views of patients during pharmacogenomic-guided care are …
inefficacy/toxicity. However, views of patients during pharmacogenomic-guided care are …
[HTML][HTML] Lessons learned when introducing pharmacogenomic panel testing into clinical practice
MB Rosenman, B Decker, KD Levy, AM Holmes… - Value in Health, 2017 - Elsevier
Objectives Implementing new programs to support precision medicine in clinical settings is a
complex endeavor. We describe challenges and potential solutions based on the Indiana …
complex endeavor. We describe challenges and potential solutions based on the Indiana …