Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

The circadian rhythm plays a fundamental role in regulating biological functions, including
sleep–wake preference, body temperature, hormonal secretion, food intake, and cognitive …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

The term social jetlag is used to describe the discrepancy between biological time,
determined by our internal body clock, and social times, mainly dictated by social obligations …

Sleep disturbances and dementia are two common and significant health problems in older
adults. Investigations suggest that sleep disturbances might increase the risk of dementia …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

Abstract Study Objectives: Mounting evidence implicates disturbed sleep or lack of sleep as
one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain. We …

Importance Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD)
and have been hypothesized to contribute to disease pathogenesis. However, it is unknown …