Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
Natural history and mechanisms of COPD
P Lange, E Ahmed, ZM Lahmar, FJ Martinez… - …, 2021 - Wiley Online Library
The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …
resulting from numerous interacting factors throughout the life cycle with smoking being the …
Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function
Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …
Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study
Background Former smokers now outnumber current smokers in many developed countries,
and current smokers are smoking fewer cigarettes per day. Some data suggest that lung …
and current smokers are smoking fewer cigarettes per day. Some data suggest that lung …
Imaging advances in chronic obstructive pulmonary disease. Insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study
SP Bhatt, GR Washko, EA Hoffman… - American journal of …, 2019 - atsjournals.org
The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …
which began in 2007, is an ongoing multicenter observational cohort study of more than …
FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease
Rationale: The diagnosis of chronic obstructive pulmonary disease (COPD) is based on a
low FEV1/FVC ratio, but the severity of COPD is classified using FEV1% predicted (ppFEV1) …
low FEV1/FVC ratio, but the severity of COPD is classified using FEV1% predicted (ppFEV1) …
Pulmonary functional imaging: Part 2—state-of-the-Art clinical applications and opportunities for improved patient care
Pulmonary functional imaging may be defined as the regional quantification of lung function
by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary …
by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary …
Voxel-wise longitudinal parametric response mapping analysis of chest computed tomography in smokers
Rationale and Objectives Chronic obstructive pulmonary disease is a heterogeneous
disease characterized by small airway abnormality and emphysema. We hypothesized that …
disease characterized by small airway abnormality and emphysema. We hypothesized that …
Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: results from SARP-3
Background Currently, there is limited knowledge regarding which imaging assessments of
asthma are associated with accelerated longitudinal decline in lung function. Objectives We …
asthma are associated with accelerated longitudinal decline in lung function. Objectives We …
Parenchymal destruction in asthma: fixed airflow obstruction and lung function trajectory
K Shimizu, N Tanabe, A Oguma, H Kimura… - Journal of allergy and …, 2022 - Elsevier
Background Fixed airflow obstruction (FAO) in asthma, particularly in nonsmokers, is
generally believed to be caused by airway remodeling. However, parenchymal destruction …
generally believed to be caused by airway remodeling. However, parenchymal destruction …