Hepatic inflammatory responses in liver fibrosis
L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies
I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …
wound healing response and can occur in various organs such as the heart, lung, liver …
Th17 cells in autoimmune and infectious diseases
JF Zambrano-Zaragoza… - International journal …, 2014 - Wiley Online Library
The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …
Dendritic cell and T cell crosstalk in liver fibrogenesis and hepatocarcinogenesis: implications for prevention and therapy of liver cancer
I Lurje, L Hammerich, F Tacke - International journal of molecular …, 2020 - mdpi.com
Liver fibrosis is a chronic, highly prevalent disease that may progress to cirrhosis and
substantially increases the risk for development of hepatocellular carcinoma (HCC). Fibrotic …
substantially increases the risk for development of hepatocellular carcinoma (HCC). Fibrotic …
Regulatory T cells (Tregs) in liver fibrosis
K Wu, Q Qian, J Zhou, D Sun, Y Duan, X Zhu… - Cell death …, 2023 - nature.com
The ability of the human liver to both synthesize extracellular matrix (ECM), as well as
regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver …
regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver …
Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response
Y Shen, SD Wu, Y Chen, XY Li, Q Zhu, K Nakayama… - Gut …, 2023 - Taylor & Francis
Gut dysbiosis has been reported in chronic hepatitis B (CHB) infection, however its role in
CHB progression and antiviral treatment remains to be clarified. Herein, the present study …
CHB progression and antiviral treatment remains to be clarified. Herein, the present study …
Mechanisms of initiation and progression of intestinal fibrosis in IBD
G Latella, J Di Gregorio, V Flati, F Rieder… - Scandinavian journal …, 2015 - Taylor & Francis
Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs). It
becomes clinically apparent in> 30% of patients with Crohn's disease (CD) and in about 5 …
becomes clinically apparent in> 30% of patients with Crohn's disease (CD) and in about 5 …
T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response
Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …
the roles that the innate immune system has on mediating tolerance or rejection of implants …
Interleukin‐17—A multifaceted cytokine in viral infections
U Sahu, D Biswas, VK Prajapati… - Journal of Cellular …, 2021 - Wiley Online Library
Viral infections are a major threat to the human population due to the lack of selective
therapeutic measures. The morbidity and mortality reported worldwide are very alarming …
therapeutic measures. The morbidity and mortality reported worldwide are very alarming …
The role of Th17 cells in viral infections
The present review provides an overview of recent advances regarding the function of Th17
cells and their produced cytokines in the progression of viral diseases. Viral infections alone …
cells and their produced cytokines in the progression of viral diseases. Viral infections alone …