Hepatic inflammatory responses in liver fibrosis

L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Th17 cells in autoimmune and infectious diseases

JF Zambrano-Zaragoza… - International journal …, 2014 - Wiley Online Library
The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …

Dendritic cell and T cell crosstalk in liver fibrogenesis and hepatocarcinogenesis: implications for prevention and therapy of liver cancer

I Lurje, L Hammerich, F Tacke - International journal of molecular …, 2020 - mdpi.com
Liver fibrosis is a chronic, highly prevalent disease that may progress to cirrhosis and
substantially increases the risk for development of hepatocellular carcinoma (HCC). Fibrotic …

Regulatory T cells (Tregs) in liver fibrosis

K Wu, Q Qian, J Zhou, D Sun, Y Duan, X Zhu… - Cell death …, 2023 - nature.com
The ability of the human liver to both synthesize extracellular matrix (ECM), as well as
regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver …

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response

Y Shen, SD Wu, Y Chen, XY Li, Q Zhu, K Nakayama… - Gut …, 2023 - Taylor & Francis
Gut dysbiosis has been reported in chronic hepatitis B (CHB) infection, however its role in
CHB progression and antiviral treatment remains to be clarified. Herein, the present study …

Mechanisms of initiation and progression of intestinal fibrosis in IBD

G Latella, J Di Gregorio, V Flati, F Rieder… - Scandinavian journal …, 2015 - Taylor & Francis
Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs). It
becomes clinically apparent in> 30% of patients with Crohn's disease (CD) and in about 5 …

T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response

KM Adusei, TB Ngo, K Sadtler - Acta Biomaterialia, 2021 - Elsevier
Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …

Interleukin‐17—A multifaceted cytokine in viral infections

U Sahu, D Biswas, VK Prajapati… - Journal of Cellular …, 2021 - Wiley Online Library
Viral infections are a major threat to the human population due to the lack of selective
therapeutic measures. The morbidity and mortality reported worldwide are very alarming …

The role of Th17 cells in viral infections

PS Aghbash, N Hemmat, JS Nahand… - International …, 2021 - Elsevier
The present review provides an overview of recent advances regarding the function of Th17
cells and their produced cytokines in the progression of viral diseases. Viral infections alone …