Premotor, nonmotor and motor symptoms of Parkinson's disease: a new clinical state of the art

ABRL Silva, RWG de Oliveira, GP Diógenes… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is a neurodegenerative disorder that affects dopaminergic
neurons in the mesencephalic substantia nigra, causing a progressive clinical course …

[HTML][HTML] Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

[HTML][HTML] NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease

WM Curtis, WA Seeds, MP Mattson, PC Bradshaw - Cells, 2022 - mdpi.com
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

Sleep and circadian rhythms in α‐synucleinopathies—perspectives for disease modification

D Kunz, H Oster, O Rawashdeh… - Acta …, 2023 - Wiley Online Library
The global north is facing an unprecedented rise in the prevalence of neurodegenerative
diseases. The increasing incidence of Parkinson's disease is being referred to as a …

[HTML][HTML] Neurological insights into sleep disorders in Parkinson's disease

S Thangaleela, BS Sivamaruthi, P Kesika, S Mariappan… - Brain sciences, 2023 - mdpi.com
Parkinson's disease (PD) is a common multidimensional neurological disorder
characterized by motor and non-motor features and is more prevalent in the elderly. Sleep …

Effect of aging and a dual orexin receptor antagonist on sleep architecture and non-REM oscillations including an REM behavior disorder phenotype in the PS19 …

K Kam, K Vetter, RA Tejiram, WD Pettibone… - Journal of …, 2023 - Soc Neuroscience
The impact of tau pathology on sleep microarchitecture features, including slow oscillations,
spindles, and their coupling, has been understudied, despite the proposed importance of …

[HTML][HTML] A mouse model of sleep disorders in Parkinson's disease showing distinct effects of dopamine D2-like receptor activation

D de Castro Medeiros, C Plewnia, RV Mendes… - Progress in …, 2023 - Elsevier
Excessive daytime sleepiness (EDS) and sleep fragmentation are often observed in
Parkinson's disease (PD) patients and are poorly understood despite their considerable …

[HTML][HTML] Physical activity and sleep pattern in relation to incident Parkinson's disease: a cohort study

LH Chen, SY Sun, G Li, X Gao, W Luo, H Tian… - International Journal of …, 2024 - Springer
Background How physical activity (PA) and different sleep traits and overall sleep pattern
interact in the development of Parkinson's disease (PD) remain unknown. Objective To …

[HTML][HTML] Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson's disease models by alleviating oxidative stress

Y Wu, Z Zhao, N Yang, C Xin, Z Li, J Xu, B Ma, KL Lim… - Antioxidants, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by progressive loss of dopaminergic neurons in the substantia nigra of the …

[HTML][HTML] Melatonin as a harmonizing factor of circadian rhythms, neuronal cell cycle and neurogenesis: additional arguments for its therapeutic use in Alzheimer's …

M Shukla, B Vincent - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
The synthesis and release of melatonin in the brain harmonize various physiological
functions. The apparent decline in melatonin levels with advanced aging is an aperture to …