Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide.
However, its toll is higher in more developed countries. Reasons for vast differences in …

The increasing utilization of heavy metals in modern industries leads to an increase in the
environmental burden. Nickel represents a good example of a metal whose use is widening …

Human exposure to highly nickel-polluted environments, such as those associated with
nickel refining, electroplating, and welding, has the potential to produce a variety of …

Chromium, like many transition metal elements, is essential to life at low concentrations yet
toxic to many systems at higher concentrations. In addition to the overt symptoms of acute …

Abstract Nickel (II), copper (II) and zinc (II) complexes with the same ligands normally display
analogous coordination geometry and binding mode toward DNA. However, although …

Worldwide, there are more than 10 million new cancer cases each year, and cancer is the
cause of approximately 12% of all deaths. Given this, a large number of epidemiologic …

It is not yet established whether oxidative stress is a major cause of cell death or simply a
consequence of an unknown pathogenetic factor. Concerning chronic diseases, as …

This article reviews the experimental data that points to formation of reactive oxygen species
(ROS) and oxidative DNA base damage as being important contributors to cancer …

Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

Several metals have been found to be carcinogenic to humans and/or animals (Tables 1
and 2). However, the underlying mechanisms remain unclear. It is believed that neoplastic …