Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized in a subpopulation of primary sensory neurons of the …

Drug repurposing has become an effective approach to drug discovery, as it offers a new
way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social …

Chronic pain determines a substantial burden on individuals, employers, healthcare
systems, and society. Most of the affected patients report dissatisfaction with currently …

Multiple sclerosis (MS) is a demyelinating, autoimmune disease that affects a large number
of young adults. Novel therapies for MS are needed considering the efficiency and safety …

The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a
promising strategy to block the virulence of the bacteria without targeting the selection …

The repair and motor functional recovery after spinal cord injury (SCI) has remained a
clinical challenge. Injury-induced gliosis and inflammation lead to a physical barrier and an …

Objective (s): Multiple sclerosis (MS) is a chronic disease of the central nervous system
(CNS) and its cause is unknown. Several environmental and genetic factors may have roles …

Pain is one of the most common symptoms experienced by patients. The use of current
analgesics is limited by low efficacy and important side effects. Transient receptor potential …

Neuron apoptosis is a feature of secondary injury after traumatic brain injury (TBI). Evidence
implies that excess calcium (Ca 2+) ions and reactive oxidative species (ROS) play critical …